Lidocaine powder,lidocaine base,cas 137-58-6,lidocaine China supplier betty@whmulei.com

Product Details
Product Name: lidocaine
Cas No.: 137-58-6
Density:1.0±0.1 g/cm3
Boiling Point:372.7±52.0 °C at 760 mmHg
Melting Point:66-69°C
Molecular Formula:C14H22N2O
Molecular Weight:234.337
Flash Point:179.2±30.7 °C
Exact Mass:234.173218
PSA:32.34000
LogP:3.63
Vapour Pressure:0.0±0.9 mmHg at 25°C
Index of Refraction:1.512
Storage condition:Store at RT
Stability:Stable. Incompatible with strong oxidizing agents.
Water Solubility:practically insoluble
EINECS: 205-302-8
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Lidocaine, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself.Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes).
Medical Uses
Local numbing agent
Heart arrhythmia
Epilepsy
Other
Intravenous lidocaine infusions are also used to treat chronic pain and acute surgical pain as an opiate sparing technique. The quality of evidence for this use is poor so it is difficult to compare it to placebo or an epidural.
Inhaled lidocaine can be used as a cough suppressor acting peripherally to reduce the cough reflex. This application can be implemented as a safety and comfort measure for patients who have to be intubated, as it reduces the incidence of coughing and any tracheal damage it might cause when emerging from anaesthesia.
Lidocaine, along with ethanol, ammonia, and acetic acid, may also help in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.

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