Lidocaine hcl powder,lidocaine hydrochloride,73-78-9,lidocaine hcl supplier

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Product Details
Product Name:Lidocaine Hydrochloride
Cas No.: 73-78-9
Boiling Point:350.8ºC at 760 mmHg
Melting Point:80-82°C
Molecular Formula:C14H23ClN2O
Molecular Weight:270.798
Flash Point:166ºC
Exact Mass:270.149902
PSA:32.34000
LogP:3.45870
Storage condition:Refrigerato
EINECS: 200-803-8
Key Words:Lidocaine hcl,lidocaine hcl powder,lidocaine hydrochloride,lidocaine hcl supplier,lidocaine hcl factory,lidocaine hcl China,lidocaine hcl manufacturer,73-78-9,cas 73-78-9
Lidocaine Hcl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx. Target:Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide–type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself.Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90–120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes).

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